Preventing Aggregation of Recombinant Interferon beta-1b in Solution by Additives: Approach to an Albumin-Free Formulation
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چکیده
منابع مشابه
Skin necrosis following a recombinant interferon-beta-1b injection.
Recombinant interferon beta-1b (INF-beta-1b) has been proven to be an effective means of treating relapsing-remitting multiple sclerosis (MS). Adverse reactions to interferon therapy have been well documented. The most common side effects are transient influenza-like symptoms, including fever, fatigue, nausea, and myalgia. Cutaneous necrosis has occasionally been reported, mostly involving smal...
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the aggregation of protein is the most prevalent and the most disturbing kind of instability and this challenge exists in almost every stage of the development of protein drug. the presence of insoluble aggregations in protein drugs will make the supply of the product a tough job. this study identifies the inhibition of the folded interferon beta 1-b’s aggregation with the assistance of some ex...
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withstand the 20 min rotation, some were not completely immune, perhaps because of residual vestibular function. Some degree of otolith function could still be present since caloric and rotational tests primarily assess horizontal semicircular canal function. It is also known that visual stimuli can provoke symptoms, and since the experiment took place in the light, this may be an alternative e...
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The Stober process is frequently used to prepare silica-coated iron oxide nanoparticles. This is usually achieved by seeding a reaction mixture consisting of water, ethanol and a catalyst with iron oxide particles and adding a silica precursor. The hydrolysis and condensation of precursor monomers results in the deposition of a silica layer on iron oxide particles. However, this process is acco...
متن کاملSynthesis of Silica-coated Iron Oxide Nanoparticles: Preventing Aggregation Without Using Additives or Seed Pretreatment
The Stober process is frequently used to prepare silica-coated iron oxide nanoparticles. This is usually achieved by seeding a reaction mixture consisting of water, ethanol and a catalyst with iron oxide particles and adding a silica precursor. The hydrolysis and condensation of precursor monomers results in the deposition of a silica layer on iron oxide particles. However, this process is acco...
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ژورنال
عنوان ژورنال: Advanced Pharmaceutical Bulletin
سال: 2015
ISSN: 2228-5881,2251-7308
DOI: 10.15171/apb.2015.068